ĐÁNH GIÁ HIỆU QUẢ GIẢI GIÃN CƠ CỦA SUGAMMADEX LIỀU 2MG/KG SAU PHẪU THUẬT NỘI SOI CẮT TÚI MẬT

Abstract

Objective: To evaluate the effectiveness of sugammadex in reversing rocuronium-induced neuromuscular blockade after laparoscopic cholecystectomy. Methods: A prospective study was conducted on 50 patients undergoing laparoscopic cholecystectomy under general anesthesia with endotracheal intubation using propofol, rocuronium, fentanyl, and sevoflurane. The degree of neuromuscular blockade was monitored using the Avance CS2 machine with the NMT module. Sugammadex 2 mg/kg was administered when TOF returned to T2. The recovery time of neuromuscular blockade (TOF reaching 0.7, 0.8, 0.9), the time to extubation, and the occurrence of residual paralysis were recorded. Results: The mean anesthesia time 100.30 ± 27.08 min; surgery 75.25 ± 20.03 min. Mean sugammadex dose 117.63 ± 22.79 mg. Recovery times from T2 to TOF 0.7, 0.8, 0.9 were 65.56 ± 26.06, 78.15 ± 30.13, and 91.85 ± 31.01 sec, respectively. Mean extubation time 106.67 ± 31.74 sec. No recurrence observed. Conclusion: Neuromuscular blockade reversal with sugammadex at a dose of 2 mg/kg after laparoscopic cholecystectomy is effective, providing rapid and safe recovery from muscle relaxation.