ĐẶC ĐIỂM VI SINH VÀ KẾT QUẢ ĐIỀU TRỊ BỆNH NHÂN VIÊM PHÚC MẠC THỨ PHÁT DO THỦNG TẠNG RỖNG TẠI BỆNH VIỆN TRUNG ƯƠNG QUÂN ĐỘI 108

Abstract

Introduction: This study aimed to describe the microbiological characteristics, antibiotic resistance patterns, and treatment outcomes of patients with secondary peritonitis at the 108 Military Central Hospital. Methods: A retrospective descriptive study was conducted on 100 patients with secondary peritonitis (75 community-acquired infections – CAI, and 25 hospital-acquired infections – HAI) from January 2022 to April 2025. Results: In the CAI group, E. coli (66%) and K. pneumoniae (42%) were the predominant isolates, showing high sensitivity (88–100%) to carbapenems and third- to fourth-generation cephalosporins. In contrast, the HAI group had a high prevalence of multidrug-resistant organisms such as P. aeruginosa (20%) and A. baumannii (24%), with carbapenem resistance rates of 82–87%. These strains remained susceptible to colistin (67–90%) and ceftazidime/avibactam (87–91%). The HAI group had a significantly higher mortality rate (60% vs. 9.3%, p < 0.01), as well as longer hospital stays, ICU durations, and mechanical ventilation time. Conclusion: There is a marked difference in microbiological profiles and resistance patterns between CAI and HAI peritonitis, significantly impacting treatment outcomes. Antibiotic regimens should be individualized based on local antibiogram data.