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IMPROVEMENT OF MOTOR FUNCTION AND QUALITY OF LIFE IN PATIENTS WITH STAGE II-III KNEE OSTEOARTHRITIS AFTER TREATMENT WITH AUTOLOGOUS PLATELET-RICH PLASMA
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Abstract
Background: Knee osteoarthritis is a chronic condition characterized by damage to the cartilage, subchondral bone, and synovial inflammation of the knee joint. If left untreated, it leads to pain and restricted knee joint mobility, thereby impacting the patient's quality of life. Autologous platelet-rich plasma (PRP) injection offers numerous advantages, including minimal side effects, safety, and a mechanism focused on regenerating and repairing damaged tissues. Objective: This study was conducted to elucidate the efficacy of autologous PRP in improving quality of life (QoL), reducing pain, and restoring knee joint function. Subjects and Methods: The study was conducted on 34 patients with primary knee osteoarthritis (KOA) stages II and III, classified according to the American College of Rheumatology (ACR) and Kellgren-Lawrence (K-L) criteria. These patients were treated with PRP at Thai Binh University Hospital from January 2023 to July 2024. Treatment efficacy was evaluated by comparing changes before and after PRP treatment at three time points, using the Visual Analogue Scale (VAS), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the Short Form-36 (SF-36) questionnaire. Results: Among the 34 patients, a majority of those over 60 years of age reported a high QoL after the third treatment (55.9% and a mean SF-36 score of 80.1 ± 11.3), with no patients reporting poor QoL. The range of motion of the knee joint increased from 110° to 130° (p<0.05). The mean VAS score, when stratified by disease stage, was 6.5 for Stage II and 4.8 for Stage III (p<0.05). Conclusion: The current study observed improvement in QOL, pain relief, and improved knee function after PRP treatment.
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Keywords
Pain; knee osteoarthritis; autologous platelet-rich plasma; quality of life; Northern Vietnam
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