CLINICAL AND IMAGING OF BILIARY BLEEDING COMPLICATIONS DUE TO PERCUTANEOUS TRANSHEPATIC CHOLANGIOSCOPIC LITHOTRIPSY WITH LASER AT HANOI MEDICAL UNIVERSITY HOSPITAL

Xuân Toàn Nguyễn, Thái Bình Nguyễn

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Abstract

Objectives: To describe the clinical and paraclinical characteristics of patients who experienced hemorrhagic complications after percutaneous transhepatic cholangioscopic lithotripsy with LASER at Hanoi Medical University Hospital. Materials and methods: A retrospective, cross-sectional descriptive study was conducted on 26 patients who developed hemorrhage requiring intervention after undergoing percutaneous transhepatic cholangioscopic lithotripsy with LASER at Hanoi Medical University Hospital from March 2020 to March 2025. Results: A total of 26 patients (mean age 63.7 ± 13.4 years, with females accounting for 61.5%) experienced biliary tract bleeding that required intervention. Pre-procedural cholangitis was noted in 76.9% of cases, and cirrhosis in 38.5%. Hemorrhage sources identified on digital subtraction angiography (DSA) included hepatic artery in 65.4% (17 patients), hepatic parenchyma in 15.4% (4 patients), hepatic and/or portal veins in 15.4% (4 patients), and both arterial and venous origins in 3.8% (1 patient). On computed tomography (CT), active bleeding from the artery was observed in 19.2% (5 patients). The mean decrease in hemoglobin was 18 g/L, and the INR increased from 1.05 to 1.26 post-procedure. Conclusion: Hemorrhage following percutaneous transhepatic cholangioscopic lithotripsy with LASER is a rare but serious complication that may result from injury to hepatic vessels or parenchyma. This complication is more likely to occur in patients with risk factors such as cholangitis, cirrhosis, or use of a large-caliber lithotripsy access port. DSA plays a pivotal role in identifying the bleeding source and managing the complication.

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References

Pulappadi VP, Srivastava DN, Madhusudhan KS. Diagnosis and management of hemorrhagic complications of percutaneous transhepatic biliary drainage: a primer for residents. British Journal of Radiology. 2021 Apr 1;94(1120):20200879.
2. Quencer KB, Tadros AS, Marashi KB, Cizman Z, Reiner E, O’Hara R, Oklu R. Bleeding after Percutaneous Transhepatic Biliary Drainage: Incidence, Causes and Treatments. Journal of Clinical Medicine. Multidisciplinary Digital Publishing Institute; 2018 May;7(5):94.
3. Schulman S, Kearon C, Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost. 2005 Apr;3(4):692–694. PMID: 15842354
4. Molina H, Chan MM, Lewandowski RJ, Gabr A, Riaz A. Complications of Percutaneous Biliary Procedures. Semin Intervent Radiol. 2021 Aug;38(3):364–372. PMCID: PMC8354729
5. Saad WEA, Davies MG, Darcy MD. Management of Bleeding after Percutaneous Transhepatic Cholangiography or Transhepatic Biliary Drain Placement. Techniques in Vascular and Interventional Radiology. 2008 Mar;11(1):60–71.
6. Mortimer AM, Wallis A, Planner A. Multiphase multidetector CT in the diagnosis of haemobilia: a potentially catastrophic ruptured hepatic artery aneurysm complicating the treatment of a patient with locally advanced rectal cancer. Br J Radiol. 2011 May;84(1001):e95-98. PMCID: PMC3473651