GIÁ TRỊ CỦA FIBRIN MONOMER VÀ D-DIMER TRONG CHẨN ĐOÁN SỚM ĐÔNG MÁU NỘI MẠCH LAN TỎA TRÊN NGƯỜI BỆNH SỐC NHIỄM KHUẨN TẠI BỆNH VIỆN ĐẠI HỌC Y DƯỢC THÀNH PHỐ HỒ CHÍ MINH

Abstract

Objective: Comparison evaluation of the diagnostic utility of Fibrin monomer and D-dimer assays for the early detection of disseminated intravascular coagulation (DIC) in patients with septic shock at University Medical Center in HCMC. Subjects and Methods: A follow-up study, all newly diagnosed septic shock patients admitted to the ICU department from June, 2023 to June, 2024. Results: A study conducted on 47 patients at the time of septic shock diagnosis found that the incidence of overt DIC was 29.79%. The average age of patients is 69.77 ± 14.54, with the majority being ≥ 60 years old; a female predominance was observed. The gastrointestinal tract represented the predominant source of infection. At the cut-off levels of 5278 ng/mL and 13.18 mg/L, respectively, FM and DD both demonstrated high sensitivity and specificity in predicting overt DIC. The AUC values of FM and DD were 0.78 and 0.84, respectively. The mean concentrations of FM and DD in patients with overt DIC were significantly higher compared with those with non-overt or non DIC (p < 0.05). Conclusion: At the early stage of septic shock diagnosis, elevated FM and DD provide comparable value in predicting overt DIC and unfavorable prognosis