ĐẶC ĐIỂM MÔ BỆNH HỌC VÀ HÓA MÔ MIỄN DỊCH U THẦN KINH NỘI TIẾT ỐNG TIÊU HÓA THEO PHÂN LOẠI TCYTTG 2022 TẠI BỆNH VIỆN BẠCH MAI

Abstract

Purpose: Determine the rate of immunohistochemical markers of neuroendocrine tumors (NEUs) according to the WHO 2022. Methods: A Cross-sectional description on 67 patients diagnosed with gastrointestinal neuroendocrine tumors at Bach Mai Hospital from 2020 to 2025. Results: The male/female ratio is 1.4/1. The average age of onset is 52.99±15.7. Neuroendocrine tumors are mainly found in the rectum, accounting for 46.3%. The most common tumor tissue structure is mixed trabecular and solid. The main histological grade is grade 1. The immunohistochemical expression rate is high. Synaptophysin is almost completely expressed at a rate of 98.5%, followed by Chromogranin A at a rate of 77.6%, and CD56 is positive at 43.3%. The Ki67 positive rate varies and Ki67 positive at a rate of <3% is the highest, accounting for 82.1%. Conclution: In neuroendocrine tumors, immunohistochemical markers are used for the definitive diagnosis and histological grade in neuroendocrine tumors. Expression of Synaptophysin, Chromogranin A and CD56 is significant in the definitive diagnosis while high Ki 67 ratio is significant in the histological grade diagnosis in neuroendocrine tumors. High histological grade is a poor prognostic factor, increasing the rate of metastasis in neuroendocrine tumors.