KẾT QUẢ ĐIỀU TRỊ KÉO DÀI THUỐC KHÁNG VI RÚT TDF TRÊN NGƯỜI BỆNH VIÊM GAN VI RÚT B MẠN TẠI VIỆN Y HỌC NHIỆT ĐỚI BẠCH MAI

Abstract

Objective: “Long-term treatment outcomes of the antiviral TDF in patients with chronic hepatitis B at the Bach Mai Institute of Tropical Medicine.” Study subjects: 206 patients diagnosed with chronic hepatitis B and treated at the Bach Mai Institute of Tropical Medicine – Bach Mai Hospital, from August 2010 to August 2024, selected by convenience sampling method. Research method: Descriptive study. Results and conclusion:The virological response rate after 6 months of TDF treatment was 56,4%, which then increased to over 80% after 18 months of treatment.The biochemical response rate varied, with the lowest at 73.3% in month 30 and the highest at 93.3% in month 78 of treatment.Among patients who were HBeAg-positive, the HBeAg response rate at 6 months of TDF treatment was 14.3%, fluctuating from a minimum of 6.7% at month 30 to a maximum of 45.4% at month 84. The HBsAg response rate after 36 months of TDF treatment was 1,7% (1/66 patients), with the lowest being 4.8% (2/42 patients) at month 60 and the highest reaching 20.0% (3/15 patients) at month 78 of treatment.