CLINICAL AND PARACLINICAL CHARACTERISTICS OF COMMUNITY-ACQUIRED PNEUMONIA IN PATIENTS WITH TYPE 2 DIABETES TREATED AT THAI NGUYEN NATIONAL HOSPITAL

Thị Hương Nhài Nông, Kim Liên Phạm, Duy Nguyên Phan

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Abstract

Objective: To describe the clinical and paraclinical characteristics of community-acquired pneumonia (CAP) in patients with type 2 diabetes mellitus treated at Thai Nguyen National Hospital. Subjects and Methods: A cross-sectional descriptive study was conducted on 117 inpatients diagnosed with CAP and with a history of type 2 diabetes mellitus, admitted from July 2024 to July 2025 at Thai Nguyen National Hospital. Results: The mean age of participants was 72.16 ± 12.30 years, with the highest proportion observed in those aged ≥ 80 years (57.2%). The male-to-female ratio was approximately 1:1.05. Common symptoms included fever (71.8%), dyspnea (53.8%), productive cough (65%), dry mouth with coated tongue (67.5%), and less frequent manifestations such as altered consciousness (11.1%), tachypnea (29.9%), and tachycardia (27.3%). Neutrophilia was present in 76.1% of cases. C-reactive protein (CRP) levels were mildly to moderately elevated in 83.8% of patients, while procalcitonin was markedly or severely elevated in 63.2%. Chest X-rays revealed diverse lesions, with multi-lobar involvement being common (right lung 21.4%, left lung 15.4%), often presenting as both consolidation and interstitial patterns. According to CURB-65, mild cases accounted for 46.2%, moderate 41.0%, and severe 12.8%. Notable biochemical predictors of severity included glucose >14 mmol/L (27.4%), urea >11 mmol/L (20.5%), hematocrit <30% (19.7%), and sodium <130 mmol/L (16.2%). Conclusion: The findings indicate that type 2 diabetic patients with CAP are typically elderly, often presenting with atypical clinical symptoms. However, paraclinical indicators such as elevated procalcitonin and CRP levels, multi-lobar involvement, and metabolic disturbances suggest severe disease progression. This underscores the need for early diagnosis, close monitoring of inflammatory markers, and strict glycemic control. Furthermore, vaccination, early recognition of respiratory symptoms, and individualized intensive treatment are essential to reduce complications and mortality.

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References

1. W. H. Organization, "Pneumonia," 2023, Available: https://www.who.int/news-room/fact-sheets/detail/pneumonia.
2. P. Saeedi et al., "Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9(th) edition," (in eng), Diabetes Res Clin Pract, vol. 157, p. 107843, Nov 2019.
3. J. A. Critchley, I. M. Carey, T. Harris, S. DeWilde, F. J. Hosking, and D. G. Cook, "Glycemic control and risk of infections among people with type 1 or type 2 diabetes in a large primary care cohort study," (in eng), Diabetes care, vol. 41, no. 10, pp. 2127-2135, 2018.
4. P. K. Liên, Giáo trình bệnh học hô hấp (Viêm phổi mắc phải cộng đồng). Hà Nội: Nhà xuất bản Y học, 2025.
5. R. K. Bhattacharya, J. D. Mahnken, and S. K. Rigler, "Impact of admission blood glucose level on outcomes in community-acquired pneumonia in older adults," (in eng), Int J Gen Med, vol. 6, pp. 341-4, 2013.
6. J. Almirall et al., "New evidence of risk factors for community-acquired pneumonia: a population-based study," (in eng), European respiratory journal, vol. 31, no. 6, pp. 1274-1284, 2018.
7. M. La, "Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults," (in eng), Clin Infect Dis., vol. 44, pp. S27-S72, 2019.
8. P. Schuetz et al., "Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections," (in eng), Evidence‐Based Child Health: A Cochrane Review Journal, vol. 8, no. 4, pp. 1297-1371, 2013.