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Date Published: 15/12/2025
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DOI: https://doi.org/10.51298/vmj.v556i3.16463
Issue
Vol. 556 No. 3 (2025)
Section
Các bài báo
How to Cite
Vũ, T. N. (2025). OUTCOME OF NEOADJUVANT CHEMOTHERAPY IN THE TREATMENT OF STAGE II TO IV NEPHROBLASTOMA AT CHILDREN’S HOSPITAL 2. Vietnam Medical Journal, 556(3). https://doi.org/10.51298/vmj.v556i3.16463

OUTCOME OF NEOADJUVANT CHEMOTHERAPY IN THE TREATMENT OF STAGE II TO IV NEPHROBLASTOMA AT CHILDREN'S HOSPITAL 2

Trường Nhân Vũ

Main Article Content

Abstract

Objective: To evaluate the treatment results of stage II to IV nephroblastoma with preoperative chemotherapy at Children's Hospital 2. Methods: Prospective cohort study. Results: There were 64 cases of stage II to IV nephroblastoma receiving neoadjuvant chemotherapy and nephrectomy after chemotherapy from April 2013 to June 2016. After preoperative chemotherapy: The median tumor volume reduced from 487.9 ± 365.3 cm3 to 206.8 ± 135 cm3 (p < 0.001). The percentage increased from 0% to 56.3% in stage I disease; decreased from 78.1% to 37.5% in stage II disease; decreased from 18.8% to 6.3% stage III disease; and decreased from 3.1% to 0% in stage IV disease (p = 0.002). Degree of response to preoperative chemotherapy: The overall response rate was 89.1%; the stable or progressive disease was 10.9%. Treatment results: The recurrence rate was 6.7%; the mortality rate was 6.7%; and the event-free survival rate was 92.2% with a mean follow-up time of 46.9 ± 14.6 months. Conclusions: Neoadjuvant chemotherapy reduces tumor volume, local invasion and distant metastasis of stage II to IV nephroblastoma, thereby reducing complications of nephrectomy and tumor removal after chemotherapy, increasing the survival rate of pediatric patients treated with chemotherapy - surgery strategy

Article Details

Keywords

Nephroblastoma, neoadjuvant chemotherapy, preoperative chemotherapy.

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