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ASSESSMENT OF HISTOPATHOLOGICAL FEATURES IN OCULAR SURFACE SQUAMOUS NEOPLASIA
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Abstract
Objective: This study describes the histopathological features and determines the frequency and morphological subtypes classification of ocular surface squamous neoplasia (OSSN) diagnosed at the Department of Laboratory, Ho Chi Minh City Eye Hospital. Methods: A retrospective, cross-sectional descriptive study was conducted on biopsy specimens diagnosed as various subtypes of OSSN at the Department of Laboratory, Ho Chi Minh City Eye Hospital, from January 2022 to December 2024. Results: A total of 188 OSSN cases were analyzed. The mean patient age was 52.9 ± 15.4 years, with a male predominance (64.9%). Regarding lesion laterality, both right and left eyes were equally affected (93 cases, 49.5% each), and bilateral involvement was observed in 2 cases (1.0%). Histopathologically, CIN 2 was the most common subtype (58.0%), followed by CIN 3 (17.0%), CIN 1 (15.4%), and squamous cell carcinoma (SCC) (9.6%). Significant associations were observed between high-grade lesions (CIN 3 and SCC) and several histological parameters, including nuclear atypia, abnormal mitotic activity, and inflammatory cell infiltration (p < 0.05). Additionally, actinic keratosis/hyperkeratosis showed a positive correlation with increasing dysplasia severity, being most frequently observed in SCC (p < 0.05). Conclusion: Histopathology plays a critical role in the definitive diagnosis of OSSN. Furthermore, the presence of actinic keratosis/hyperkeratosis appears to be associated with increasing histological malignancy, suggesting its potential prognostic value in the pathological assessment of OSSN
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Keywords
Ocular surface squamous neoplasia, OSSN, conjunctival intraepithelial neoplasia, CIN
References
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