ĐÁNH GIÁ TÌNH TRẠNG THIẾU MÁU VÀ LIÊN QUAN CHILD-PUGH Ở NGƯỜI BỆNH VIÊM GAN MẠN TÍNH VÀ XƠ GAN DO HBV

Abstract

Objective: To assess anemia among patients with hepatitis B virus (HBV)-related hepatitis and HBV-related cirrhosis. Methods: A cross-sectional descriptive study was conducted, comparing three groups: chronic HBV-related hepatitis (CHB, n = 25), patients with HBV-related cirrhosis (HBC, n = 25), and a control group (HC) of 50 healthy individuals without clinical or subclinical abnormalities at the time of study. Results: Red blood cell count (RBC), hemoglobin (HGB), and hematocrit (HCT) levels were significantly reduced in the HBC group compared to the CHB and HC groups (p < 0.0001). No significant differences were observed between the CHB and HC groups in these parameters. The prevalence of anemia in the HBC group was 72.0%. The mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were significantly higher in the HBC group than in controls, while the mean corpuscular hemoglobin concentration (MCHC) remained comparable across all groups, suggesting a macrocytic anemia pattern in patients with HBC. Moreover, a progressive decrease in RBC, HGB, and HCT values was observed across Child - Pugh classifications from A to C (p < 0.05). Conclusion: Anemia is frequently observed in HBC patients, with a prevalence of 72.0%, but is uncommon in those with CHB. Anemia correlates positively with increasing Child - Pugh class severity. The anemia observed in HBC is characterized as macrocytic, as indicated by elevated MCV and MCH values.