MỐI TƯƠNG QUAN GIỮA NỒNG ĐỘ HCV CORE ANTIGEN (HCVCAG) VỚI TẢI LƯỢNG HCV-RNA Ở NGƯỜI BỆNH NHIỄM VI RÚT VIÊM GAN C ĐIỀU TRỊ TẠI VIỆN Y HỌC NHIỆT ĐỚI BẠCH MAI

Abstract

Objective: To investigate the correlation between the concentration of HCVcAg and HCV-RNA in patients with hepatitis C virus (HCV) infection at the Bach Mai Institute of Tropical Medicine – Bach Mai Hospital. Subjects and Methods: A retrospective cross-sectional study was conducted on 66 patients with HCV infection who were examined and treated at the Bach Mai Institute of Tropical Medicine – Bach Mai Hospital from November 2016 to December 2020. Results and Conclusion: There was a very strong correlation between HCVcAg and HCV-RNA viral load (r=0.76, p=0.000), with a very strong correlation observed in male patients (r=0.86, p=0.000) and a strong correlation in female patients (r=0.55, p=0.01). The correlation between HCVcAg and HCV-RNA viral load was moderate when HCV-RNA <5log (r=0.31, p=0.03), and strong when HCV-RNA ≥5log (r=0.6, p=0.000). A very strong correlation was found between HCVcAg and HCV-RNA when AST ≤ 2ULN and ALT ≤2ULN, with r=0.95 (p=0.000) and r = 0.93 (p=0.000), respectively. When AST and ALT were >2ULN, the correlation remained strong, with r=0.56 (p=0.000) and r=0.69 (p =0.000), respectively. HCVcAg showed a strong correlation with HCV-RNA viral load regardless of platelet count and serum albumin levels.