Article Sidebar

pdf
Date Published: 15/12/2025
Abstract Views: 0
Views pdf: 0
DOI: https://doi.org/10.51298/vmj.v556i3.16535
Issue
Vol. 556 No. 3 (2025)
Section
Các bài báo
How to Cite
Trương, T. H., Nguyễn, T. T., & Phạm, X. P. (2025). TO EVALUATE THE THERAPEUTIC EFFECTIVENESS OF TREATING CHRONIC GOUT WITH HYPERURICEMIA AT THE TRADITIONAL MEDICINE HOSPITAL OF THE MINISTRY OF PUBLIC SECURITY. Vietnam Medical Journal, 556(3). https://doi.org/10.51298/vmj.v556i3.16535

TO EVALUATE THE THERAPEUTIC EFFECTIVENESS OF TREATING CHRONIC GOUT WITH HYPERURICEMIA AT THE TRADITIONAL MEDICINE HOSPITAL OF THE MINISTRY OF PUBLIC SECURITY

Thị Huyền Trương, Trọng Thông Nguyễn, Xuân Phong Phạm

Main Article Content

Abstract

Objective: To evaluate the therapeutic effectiveness of treating chronic gout with hyperuricemia at the Traditional Medicine Hospital of the Ministry of Public Security. Methods: A prospective, open-label clinical trial comparing pre- and post-treatment changes and a control group. A total of 120 patients with chronic gout and hyperuricemia were divided into two groups: the study group received GT1 film-coated tablets, and the control group received Allopurinol for 30 days. Results: After 30 days of treatment, the mean reduction in serum uric acid in the study group was 107.25 µmol/L; 70% of patients achieved target uric acid levels, which was lower than in the control group (93.33%). Treatment responses were classified as: good 25%, fair 61.67%, moderate 13.33%, with no poor responses. Conclusion: GT1 showed urate-lowering effects and clinical improvement but had lower uric-acid–lowering efficacy compared with Allopurinol. GT1 was safe, well tolerated, and may be used for patients who cannot tolerate Allopurinol or as an adjunctive therapy.

Article Details

Keywords

chronic gout, hyperuricemia.

References

Paulino YC, Camacho F, Paulino TV, et al. (2025). Conducting genetic epidemiology research on hyperuricaemia and gout in an indigenous community in Guam-a feasibility study. BMC public health, 25(1), 484.
2. FitzGerald JD (2025). Gout. Annals of internal medicine, 178(3), Itc33-itc48.
3. He Q, Mok TN, Sin TH, et al. (2023). Global, Regional, and National Prevalence of Gout From 1990 to 2019: Age-Period-Cohort Analysis With Future Burden Prediction. JMIR public health and surveillance, 9, e45943.
4. Xu H, Wang P, Fu H, et al. (2025). Serum urate levels alter the spatial distribution of urate crystals in synovium and correlate with synovitis and pain in non-gout female patients with anteromedial knee osteoarthritis. Arthritis & rheumatology (Hoboken, NJ).
5. Morlock R, Chevalier P, Horne L, et al. (2016). Disease control, health resource use, healthcare costs, and predictors in gout patients in the United States, the United Kingdom, Germany, and France: a retrospective analysis. Rheumatology (Oxford, England), 3, 53-75.
6. Tạ Đăng Quang (2020). Nghiên cứu độc tính và tác dụng điều trị bệnh gút mạn tính của viên nang cứng Tam diệu gia vị trên thực nghiêm và lâm sàng. Luận án tiến sỹ, Trường Đại học Y Hà Nội.
7. Nguyễn Thị Tuyết Minh (2018). Nghiên cứu độc tính và tác dụng hỗ trợ điều trị bệnh gút mạn của cốm tan Tứ diệu tán. Luận án tiến sỹ.
8. Nuki G, Doherty M, Richette PJ (2017). Current management of gout: practical messages from 2016 EULAR guidelines. Pol Arch Intern Med, 127(4), 267-77.