CA BỆNH HIẾM GẶP ANNULAIRE ELASTOLYTIC GIANT CELL GRANULOMA: PHÁT HIỆN MỚI TRÊN LÂM SÀNG VÀ CƠ CHẾ BỆNH SINH

Abstract

Objectives: To describe the clinical features, paraclinical findings, and pathogenesis of a case of annular elastolytic giant cell granuloma at Hanoi Dermatology Hospital, thereby contributing evidence to the inflammatory hypothesis and the metabolic disease–related pathogenesis of this condition. Subjects and Methods: Case report. The patient was a 52-year-old female with a history of type 2 diabetes mellitus, presenting with clinical lesions located in non–sun-exposed areas, including the palms and lateral aspects of the fingers. The patient had no history of prolonged sun exposure. Histopathologic examination showed granulomatous inflammatory response with elastolysis and elastophagocytosis. Elastolysis and elastophagocytosis were further confirmed by special staining Van Gieson (EVG). Other laboratory tests and special stains excluded other granulomatous dermatoses. Results: The case was definitively diagnosed as annular elastolytic giant cell granuloma. By comparing this case with classical cases previously described in the literature, we provide additional evidence supporting the inflammatory and metabolic-related hypothesis, particularly the association with diabetes mellitus. Conclusion: This case highlights the need for more in-depth studies with histopathologic validation to elucidate the role of inflammation and metabolic disorders in the pathogenesis of this condition.