SỰ THAY ĐỔI HIỆU GIÁ KHÁNG THỂ KHÁNG TREPONEMA PALLIDUM TRƯỚC VÀ SAU ĐIỀU TRỊ BỆNH GIANG MAI GIAI ĐOẠN SỚM TẠI BỆNH VIỆN DA LIỄU HÀ NỘI, 2022-2023

Abstract

Objective: To evaluate the change in syphilitic antibody titers of the two semi-quantitative tests, RPR and TPHA, before and after treatment. Subjects and Methods: This was a descriptive study combining retrospective and prospective analysis of 118 newly diagnosed syphilis patients with both semi-quantitative RPR and TPHA tests, who were examined at Hanoi Dermatology Hospital from January 2022 to October 2023. Results: Before treatment, 67.8% had RPR SATs ≥ 1/16, and 55.1% had TPHA SATs ≥ 1/10,240. After treatment: at 1 month, no cases had a ≥ 4-fold reduction in RPR or TPHA SATs; at 3 months, 30.8% had ≥ 4-fold reduction in RPR SATs and 15.4% in TPHA SATs. At 6 months, 44.4% had ≥ 4-fold reduction in RPR SATs and 33.3% in TPHA SATs. At 9 and 12 months, 100% showed RPR seroconversion and 100% had ≥ 4-fold reduction in TPHA SATs. Conclusion: Performing semi-quantitative RPR and TPHA tests before treatment is essential. Newly diagnosed syphilis patients need follow-up antibody titers at 3, 6, 9, and 12 months after treatment to assess disease progression and prevent transmission to sexual partners.