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COMPARISON OF RAPID PLASMA REAGIN TEST VALUE OF RPR AND TREPONEMA PALLIDUM HEMAGGLUTIATION’S TPHA IN DIAGNOSIS AND SCREENING FOR SYPHILIS
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Abstract
Objective: To compare the value of qualitative tests RPR and TPHA in diagnosing and screening for syphilis at Hanoi Dermatology Hospital in 2023. Method: Patients coming for examination were assigned to qualitatively test both RPR and TPHA, with a comparative, descriptive cross-sectional method, both retrospective and prospective, on a total of 173 samples at Hanoi Dermatology Hospital from January 2022 to October 2023. Results: Of the 173 positive samples, 116 (67%) were positive for TPHA and 87 (51.3%) were positive for RPR. Using the TPHA specific test as the gold standard for diagnosing syphilis, the RPR test had a sensitivity, specificity, positive predictive value, and negative predictive value of 74.1%; 98.2%; 98.9%; and 65.1%, respectively. The agreement rate and Cohen's Kappa coefficient between the TPHA test and the RPR test were 82.1% and 0.68. Conclusion: The results of the study show that the two tests TPHA and RPR are very reliable in supporting the diagnosis and screening of syphilis. Both RPR and TPHA tests should be ordered to avoid missing cases due to false positive biological results or false negative results in stage I and II syphilis.
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Keywords
RPR, TPHA, Treponema pallidum, syphilis
References
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