ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG CỦA BỆNH NHÂN XƠ GAN RƯỢU CÓ ĐÁI THÁO ĐƯỜNG TẠI TRUNG TÂM TIÊU HÓA - GAN MẬT, BỆNH VIỆN BẠCH MAI NĂM 2024-2025

Abstract

Objective: To investigate the clinical and subclinical characteristics of patients with alcoholic cirrhosis and diabetes. Subjects and Methods: A cross-sectional descriptive study of 68 patients diagnosed with alcoholic cirrhosis and diabetes from August 2024 to May 2025. Results: The average age was 57.13±8.05, and 100% were male. They had a history of alcohol use for over 20 years, and 50% of patients had an AUDIT score > 20 points. Clinical symptoms of liver dysfunction included fatigue, loss of appetite (66.1%); jaundice (45.6%); vomiting, bloody stools (38.2%), ascites (57.4%), and anemia (55.8%). The majority of patients had reduced hemoglobin, platelets, and prothrombin levels. At the time of admission, 55.9% of patients had a blood glucose level ≥ 11.1 mmol/L, while only 1 patient had a blood glucose level < 3.9 mmol/L. The average values of liver enzymes tended to increase: ALT: 81.52±170.39 U/L, AST: 132.4±189.19 U/L, GGT: 471.54±427.07 U/L. Endoscopy images showed mostly esophageal varices, with grade III varices accounting for 58.8%. Regarding complications of cirrhosis, the most common were ascites (70.6%), gastrointestinal bleeding (38.2%); hepatic encephalopathy (19.1%); hepatorenal syndrome (4.4%), and spontaneous bacterial peritonitis (3.0%). Conclusion: Patients with alcoholic cirrhosis and diabetes were mostly hospitalized for hyperglycemia or hypoglycemia accompanied by complications of cirrhosis