MỐI LIÊN QUAN GIỮA NỒNG ĐỘ HS-CRP VÀ TỔN THƯƠNG GIẢI PHẪU ĐỘNG MẠCH VÀNH Ở BỆNH NHÂN HỘI CHỨNG VÀNH CẤP

Abstract

Introduction: Inflammation plays a central role in the pathogenesis of acute coronary syndrome (ACS), contributing to plaque instability and thrombus formation. High-sensitivity C-reactive protein (hs-CRP) is a well-recognized biomarker of systemic inflammation and has been proposed as a potential marker of disease severity in ACS. Objective: This study aimed to investigate the relationship between plasma hs-CRP levels and the anatomical severity of coronary artery disease in patients with ACS. Methods: This retrospective cross-sectional descriptive study included 80 patients with ACS admitted to Cho Ray Hospital from September 2006 to September 2007. All patients underwent coronary angiography within 24 hours of admission, and plasma hs-CRP levels were measured using a high-sensitivity immunoassay. The extent of coronary artery disease was assessed by the number of vessels with ≥50% stenosis and the Gensini score. Statistical analyses included ANOVA, Pearson’s correlation, and multivariate linear regression adjusting for conventional cardiovascular risk factors. Results: The mean age was 61 ± 12 years, and 68.7% were male. The mean hs-CRP level within the first 48 hours was 42.96 ± 23.5 mg/L. hs-CRP levels increased progressively with the number of diseased coronary vessels (1-vessel: 27.3 mg/L; 2-vessel: 39.8 mg/L; ≥3-vessel: 58.4 mg/L; p < 0.01). hs-CRP was moderately correlated with the Gensini score (r = 0.41; p < 0.01). After adjustment for conventional risk factors, hs-CRP remained an independent predictor of extensive coronary anatomical involvement (β = 0.33; p = 0.02). Conclusion: Elevated plasma hs-CRP levels are significantly associated with the extent of coronary anatomical lesions in patients with ACS. hs-CRP measurement may provide additional value for anatomical risk stratification alongside conventional imaging-based assessments