MỐI LIÊN QUAN GIỮA TỈ SỐ TIỂU CẦU – LYMPHO BÀO VỚI ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ ĐIỀU TRỊ Ở BỆNH NHÂN NHỒI MÁU CƠ TIM CẤP

Abstract

Background: Acute myocardial infarction (AMI) is a leading cause of cardiovascular mortality in Viet Nam. Although prognostic scoring systems and cardiac biomarkers have contributed substantially to improving outcomes, in-hospital adverse events remain common, especially in primary and lower-level healthcare settings. Therefore, simpler and more practical prognostic tools are needed. Objective: To investigate the association between the platelet-to-lymphocyte ratio (PLR) and clinical, paraclinical characteristics, as well as treatment strategies, in patients with AMI. Methods: This was a retrospective analytical study on 112 patients with AMI admitted to the Interventional Cardiology Department, University Medical Center Ho Chi Minh City, from January 2023 to January 2025. Patients were stratified into two groups according to PLR values (>153 vs. ≤153). Results: Compared with the low-PLR group, patients with high PLR had higher heart rates (91.5 vs. 83.7 bpm), lower blood pressures, a higher proportion of STEMI (76.1% vs. 35.6%), more Killip class ≥ II (47.8% vs. 13.3%), and more GRACE high-risk scores (44.8% vs. 20%). High-PLR patients also showed higher levels of high-sensitivity troponin T, NT-proBNP, glucose, and creatinine, and lower eGFR. They more frequently received spironolactone (73.1% vs. 26.7%), dobutamine (32.8% vs. 8.9%), and noradrenaline (26.9% vs. 8.9%). Conclusion: High PLR is associated with more severe clinical presentation and increased need for intensive supportive therapy among patients with AMI. PLR may serve as a simple and practical prognostic marker in routine clinical practice