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Date Published: 26/12/2025
Abstract Views: 95
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DOI: https://doi.org/10.51298/vmj.v557i1.16619
Issue
Vol. 557 No. 1 (2025)
Section
Các bài báo
How to Cite
Lưu, N. M., Đoàn, T. P. L., Vũ, V. G., & Trần, Đức H. (2025). MEAN PLATELET VOLUME IN PATIENTS WITH ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. Vietnam Medical Journal, 557(1). https://doi.org/10.51298/vmj.v557i1.16619

MEAN PLATELET VOLUME IN PATIENTS WITH ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Ngọc Mai Lưu, Thị Phương Lan Đoàn, Văn Giáp Vũ, Đức Hùng Trần

Main Article Content

Abstract

Objective: To assess the utility of mean platelet volume (MPV) in identifying acute exacerbations of COPD (AECOPD) and predicting severity. Methods: Prospective cross-sectional study of 412 COPD patients (inpatients = 128; outpatients = 284), including 177 AECOPD and 235 stable cases (Aug-2023 to Sep-2024, Bach Mai Hospital). Pulmonary function, hematology/biochemistry, platelet indices and MPV were collected and analyzed (SPSS 20; ROC for MPV cut-off). Results: Mean age 71 ± 9 years; male predominance. Overall FEV₁(%) 43.45 ± 16.36 with non-significant differences between AECOPD and stable groups. MPV cut-off 7.95 fL, AUC = 0.94 (p<0.001), sensitivity = 84%, specificity = 84% for distinguishing AECOPD from stable COPD. MPV rose from day 1→4→7; MPV ≥ 7.95 associated with higher Anthonisen severity (Types 2, 3). Conclusions: MPV is a practical marker to support AECOPD identification and severity stratification; the 7.95 fL cut-off shows strong  diagnostic performance.

Article Details

Keywords

Mean platelet volume (MPV), Chronic Obstructive Pulmonary Disease (COPD).

References

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