KHẢO SÁT ĐẶC ĐIỂM LÂM SÀNG VÀ TÍNH KHÁNG KHÁNG SINH TRÊN BỆNH NHÂN NHIỄM BURKHOLDERIA PSEUDOMALLEI TẠI BỆNH VIỆN ĐA KHOA TỈNH KIÊN GIANG

Abstract

Introduction: B. pseudomallei is a bacterium that causes infections in humans and animals, commonly known as Whitmore's disease. The disease occurs in both adults and children, presenting with diverse clinical manifestations and affecting individuals of all ages. Despite appropriate treatment, it is associated with a high mortality rate. Objective: Description of Clinical Characteristics and Antibiotic Resistance of B. pseudomallei at Kien Giang General Hospital. Methods: A retrospective and prospective case series study was conducted from October 2022 to October 2023. Results and Conclusion: The study included 16 patients infected with B. pseudomallei. The male-to-female ratio was 10:6, and the age group of 40–60 years accounted for the highest infection rate 62,5%. Most patients were treated in the Intensive Care Unit, making up 56,4% of cases. The most common risk factor was diabetes mellitus, present in 68,7% of the patients. The highest rate of B. pseudomallei isolation was from blood samples 87,6%. Leukocytosis in 56,2% of patients, with increased neutrophils in 93,8%. Procalcitonin levels were elevated in 87,5%, and C-reactive protein (CRP) levels were elevated in 12,5%. Antibiotic susceptibility testing showed that B. pseudomallei was 100% sensitive to Ceftazidime, Sulfamethoxazole/ Trimethoprim, and Amoxicillin/Clavulanate. It was 93,8% sensitive to Imipenem and Tetracycline.