ĐÁNH GIÁ KẾT QUẢ GHÉP GAN TỪ NGƯỜI HIẾN CHẾT NÃO TIÊU CHUẨN MỞ RỘNG TẠI BỆNH VIỆN HỮU NGHỊ VIỆT ĐỨC

Abstract

Objective: To evaluate the characteristics of donors and recipients and the outcomes of liver transplantation using extended criteria donor (ECD) deceased donors at Viet Duc University Hospital from January 2012 to December 2023. Methods: A retrospective descriptive study; convenience sampling was used to select cases of liver transplantation from ECD deceased donors. Primary endpoints included donor/recipient characteristics, early (≤90 days) and late (>3 months) complications, ICU/hospital stay duration, 90-day mortality, and survival time. Results: A total of 65 liver transplant recipients were included, of which 25 (38.5%) received ECD livers. Common ECD criteria were Na⁺ >170 mmol/L (12%), bilirubin >34 µmol/L (12%), and 4 donors had ≥2 criteria. Among recipients: 93.8% were male; mean age was 52.1 years; primary indications were HCC (>65%) on a background of hepatitis B (>80%). ICU stay (4.7±1.7 vs. 5.2±2.3 days; p=0.35) and hospital stay (27.2±8.3 vs. 27.0±10.2 days; p=0.91) were comparable between ECD and control groups. Early complications in the ECD group included graft rejection (4%) and primary graft dysfunction (4%). Ninety-day mortality was 8% (ECD) compared to 2.5% (control group). No significant difference in survival time was observed between the two groups. Conclusion: Liver transplantation using ECD deceased donors yields comparable survival outcomes; however, the higher risk of severe complications and 90-day mortality in the ECD group warrants attention. The results suggest that ECD use is safe in the context of organ shortage, provided appropriate selection criteria and careful assessment protocols are applied