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URINE OUTPUT KINETICS IN THE VERY EARLY PHASE IN PATIENTS WITH ACUTE HEART FAILURE
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Abstract
Introduction: Loop diuretics are the cornerstone treatment in patients with acute heart failure. However, the response to loop diuretics, as measured by urine output, has not been extensively studied in Vietnam. This study was conducted to evaluate the kinetics of urine output within the first 24 hours in patients with acute heart failure. Methods: A descriptive cross-sectional study was performed on patients with acute heart failure admitted between January 2025 and July 2025. Results: A total of 76 patients meeting the inclusion criteria were enrolled, with a mean age of 65.9 ± 13.9 years, and 59.2% were male. The rate of diuretic resistance was 26.3%. There was a significant difference (p < 0.001) in urine output between the diuretic-resistant and non-resistant groups as early as 30 minutes and 1 hour after hospital admission. Conclusion: The study demonstrates that differences in urine output occur very early after the administration of loop diuretics in patients with acute heart failure.
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Keywords
acute heart failure, loop diuretics, diuretic resistance, diuretic response.
References
2. Meekers E, Dauw J, ter Maaten JM, Martens P, Nijst P, Verbrugge FH, Van Es M, Erzeel J, Damman K, Trullàs JC et al: Urinary sodium analysis: The key to effective diuretic titration? European Journal of Heart Failure expert consensus document. European Journal of Heart Failure 2025, 27(6):940-949.
3. Wu L, Rodriguez M, El Hachem K, Krittanawong C: Diuretic Treatment in Heart Failure: A Practical Guide for Clinicians. J Clin Med 2024, 13(15).
4. Horiuchi Y, Wettersten N: Treatment strategies for diuretic resistance in patients with heart failure. Journal of Cardiology 2025, 85(1):1-7.
5. Mocan D, Jipa R, Jipa DA, Lala RI, Rasinar FC, Groza I, Sabau R, Sulea Bratu D, Balta DF, Cioban ST et al: Unveiling the Systemic Impact of Congestion in Heart Failure: A Narrative Review of Multisystem Pathophysiology and Clinical Implications. Journal of Cardiovascular Development and Disease 2025, 12(4):124.
6. Damman K, Ter Maaten JM, Coster JE, Krikken JA, van Deursen VM, Krijnen HK, Hofman M, Nieuwland W, van Veldhuisen DJ, Voors AA et al: Clinical importance of urinary sodium excretion in acute heart failure. Eur J Heart Fail 2020, 22(8):1438-1447.
7. Baumberger J, Dinges S, Lupi E, Wolters T, Stüssi-Helbling M, Cippà PE, Bellasi A, Huber LC, Arrigo M: Prevalence and characteristics of upfront diuretic resistance in acute heart failure: The P-Value-AHF study. ESC Heart Fail 2025, 12(1):688-694.
8. Fujimoto Y, Kitai T, Nasu T, Matsumoto S, Naruse Y, Hioki H, Shimizu M, Yonetsu T, Horiuchi Y, Matsue Y: The dynamics of urine sodium concentration after intra-venous furosemide in patients with acute heart failure. European Heart Journal 2024, 45(Supplement_1).