CHỈ SỐ SAI: DẤU ẤN MỚI TRONG ĐÁNH GIÁ VIÊM LIÊN QUAN ĐẾN SUY GIẢM CHỨC NĂNG THẬN Ở BỆNH NHÂN ĐÁI THÁO ĐƯỜNG TÍP 2

Abstract

Background: Chronic low-grade inflammation contributes to insulin resistance and exacerbates vascular complications and metabolic disorders in patients with type 2 diabetes mellitus. Recently, the Systemic Immune-Inflammation Index (SII) has emerged as a widely studied biomarker reflecting low-grade inflammation in chronic diseases. In addition, age is a significant factor influencing both inflammation and immune function, with older individuals exhibiting higher levels of chronic inflammation. Therefore, this study proposes a novel marker—the SAI (SII-Age Index)—which integrates SII and age and investigates the association between SAI and renal function decline in patients with type 2 diabetes. Methods: This cross-sectional study analyzed 143 patients with type 2 diabetes mellitus who attended the outpatient clinic at the University Medical Center Ho Chi Minh City – Campus 2, between August 2024 and March 2025. Results: The mean value of the SAI was 19.9 with a standard deviation of 1.8. The SAI showed a positive correlation with the duration of diabetes (r = 0.26, p < 0.05), a positive correlation with the albumin-to-creatinine ratio (ACR) (r = 0.18, p < 0.05), a positive correlation with serum creatinine levels (r = 0.20, p < 0.05), and a negative correlation with estimated glomerular filtration rate (eGFR) (r = -0.52, p < 0.01). Conclusions: The SAI may serve as a useful tool for assessing chronic inflammation and could be integrated into the monitoring of renal function decline in patients with type 2 diabetes mellitus.