TƯƠNG QUAN CỦA CHỈ SỐ TRIGLYCERIDE-GLUCOSE VỚI MỨC ĐỘ NẶNG TỔN THƯƠNG MẠCH VÀNH Ở BỆNH NHÂN BỆNH ĐỘNG MẠCH VÀNH MẠN

Abstract

Background: Coronary artery disease (CAD) is a leading cause of cardiovascular morbidity and mortality. The triglyceride–glucose (TyG) index, reflecting insulin resistance, has been proposed as a simple, inexpensive biomarker for atherosclerosis and cardiovascular risk, yet evidence in chronic CAD populations, particularly in Vietnam, is limited. Objective: To evaluate the correlation between the triglyceride–glucose (TyG) index and the severity of coronary artery lesions assessed by the Gensini score in patients with chronic coronary artery disease, and to determine the predictive value of TyG for severe lesions. Methods: A cross-sectional study was conducted on patients with chronic coronary syndrome who underwent coronary angiography at Gia Dinh People’s Hospital from January 2025 to June 2025. Results: Among 148 patients (mean age 63.6 ± 9.2 years, 70.9% male), hypertension (88.5%), dyslipidemia (81.1%), diabetes (52.7%), and smoking (41.2%) were common. Median Gensini score was 35 (IQR: 8.5–75.0). Glucose, triglyceride, and TyG increased across tertiles (p < 0.05). TyG showed a moderate positive correlation with Gensini (Spearman’s rho = 0,475; p < 0,001). ROC analysis showed TyG predicted severe CAD with an AUC of 0.709 (95% CI: 0.619–0.798). The optimal cutoff was 9.11 (sensitivity 73.5%, specificity 62.6%, NPV 82.7%, PPV 49.3%). Conclusions: The TyG index correlates significantly with coronary lesion severity and moderately predicts severe CAD. A threshold of ≥9.11 may be useful as a simple, low-cost tool for screening and risk stratification in chronic CAD patients.