KẾT QUẢ ĐIỀU TRỊ UNG THƯ VÚ GIAI ĐOẠN I-II TẠI TRUNG TÂM UNG BƯỚU BỆNH VIỆN ĐA KHOA TỈNH THÁI BÌNH

Abstract

Objective: To describe the clinical and paraclinical characteristics of patients with stage I–II breast cancer and to evaluate treatment outcomes in this patient group. Subjects and methods: A retrospective descriptive study was conducted on 126 patients with stage I–II breast cancer who underwent surgery and follow-up at Thai Binh General Hospital between 2019 and 2023. Results: The study showed that breast cancer patients had a mean age of 59.3 years, with the majority being postmenopausal (75.4%). The most common presenting symptom was self-detected breast lumps (73.8%), predominantly located in the upper outer quadrant, with tumor sizes of 2–5 cm; about 30.2% had N1 lymph node metastasis. Histopathologically, invasive ductal carcinoma predominated (91.3%), mostly grade II. All patients underwent modified radical mastectomy combined with multimodal adjuvant therapy, including chemotherapy (94.4%), radiotherapy (42.9%), and endocrine therapy (61.1%). Postoperative complications mainly included psychological disorders, axillary nerve injury, and wound pain, while severe complications were uncommon. During follow-up, 96.8% of patients remained alive, with a mortality rate of 3.2% and recurrence/metastasis rate of 9.5%, mainly distant metastases. The 5-year overall survival (OS) rate was 96.3%, and disease-free survival (DFS) was 89.5%. Multivariate analysis revealed no statistically significant differences in OS or DFS according to nodal status, tumor size, histological type, or grade, although patients without nodal metastasis and with lower histological grade tended to have better prognosis (p > 0.05). Conclusion: The application of surgery combined with multimodal therapy for stage I–II breast cancer at the Oncology Center of a provincial general hospital has yielded promising outcomes, with treatment results comparable to those of central specialized hospitals