HIỆU QUẢ LỌC MÁU HẤP PHỤ KẾT HỢP LỌC MÁU LIÊN TỤC TRONG HỖ TRỢ ĐIỀU TRỊ VIÊM TUỴ CẤP NẶNG

Abstract

Objective: To assess the effectiveness of hemoperfusion combined with continuous renal replacement therapy (CRRT) in improving SOFA score and serum cytokine levels in patients with severe acute pancreatitis. Subjects: Patients with severe acute pancreatitis who were indicated for hemoperfusion combined with CRRT at the Center for Critical Care Medicine – Bach Mai Hospital from August 2024 to September 2025. Methods: A retrospective descriptive observational study included all patients with severe acute pancreatitis who treated hemoperfusion combined with CRRT during the study period, data were collected from medical records and case report forms and analyzed using SPSS. Results: Among the 30 enrolled patients, males accounted for the majority (80%), with a mean age of 46.6 ± 11.9 years. Prior to hemoperfusion combined with CRRT, mean SOFA score was 6.4 ± 2.9; mean intra-abdominal pressure (IAP, cmH₂O) was 28.8 ± 4.8; mean CTSI was 8.0 ± 1.1, and mean serum interleukin-6 (IL-6, pg/mL) level was 913.4 ± 670.9. Average number of hemoperfusion was 2.37 ± 0.77 times per patient. Clinical parameters improved significantly, with SOFA score decreased to 4.7 ± 2.3; IAP reduced to 18.6 ± 3.6cmH₂O, accompanied by a statistically significant reduction in serum IL-6 levels to 141.8 ± 49.7pg/mL (p < 0.01). Conclusion: Hemoperfusion combined with CRRT contributes to significant improvement in organ dysfunction (SOFA score), intra-abdominal pressure, and IL-6 levels in patients with severe acute pancreatitis.