XÁC ĐỊNH TỶ LỆ TƯƠNG TÁC THUỐC ĐIỀU TRỊ TĂNG HUYẾT ÁP TRÊN BỆNH NHÂN NGOẠI TRÚ TẠI TRUNG TÂM Y TẾ NGUYỄN VĂN THỦ - HUYỆN VŨNG LIÊM, TỈNH VĨNH LONG NĂM 2024

Abstract

Objective: To investigate the current status of drug use and determine the rate of drug–drug interactions among hypertensive outpatients at Nguyen Van Thu Medical Center, Vung Liem District, Vinh Long Province in 2024. Subjects and Methods:  A cross-sectional descriptive and analytical study with a retrospective, non-interventional design was conducted on 392 prescriptions and medical records of hypertensive outpatients treated at Nguyen Van Thu Medical Center, Vung Liem District, Vinh Long Province from January 2024 to December 2024. Results: The average number of drugs per prescription was 6.19 ± 1.60, with 83.4% of prescriptions contain 5 or more drugs. Calcium channel blockers were the most frequently used group 60.5%. The proportion of prescriptions with DDIs was 87.8%, of which 37.8% involved interactions among antihypertensive drugs and 82.1% involved interactions between antihypertensive and non-antihypertensive drugs. A total of 71.7% of DDIs were clinically significant, with 60.5% occurring between antihypertensive agents. Conclusion: The study identified clinically significant factors associated with drug interactions, including age, number of comorbidities, number of prescribed medications, and the presence of diabetes mellitus, ischemic stroke, angina pectoris, and ischemic heart disease. K