ĐÁNH GIÁ HIỆU QUẢ CAN THIỆP DINH DƯỠNG TRÊN BỆNH NHÂN UNG THƯ ĐẠI TRỰC TRÀNG ĐƯỢC PHẪU THUẬT TẠI BỆNH VIỆN BÌNH DÂN NĂM 2024 - 2025

Abstract

Objective: To compare the effectiveness of a perioperative nutritional intervention on weight and PG-SGA score between an intervention and a control group of patients undergoing surgery for colorectal cancer at Binh Dan Hospital during 2024-2025. Methods: This prospective, controlled study involved 120 colorectal cancer surgery patients, matched by propensity score into intervention and control groups (n=40/group). The intervention group received a new protocol with early enteral nutrition and supplemental parenteral nutrition, compared against the control group receiving standard care. Results: Compared to the control group, the intervention group showed a higher rate of nutritional status improvement according to PG-SGA (22.5% vs. 5.0%) and a lower rate of deterioration (17.5% vs. 32.5%) (p=0.043). Weight loss was significantly lower in the intervention group (median: -1.00 kg [-3.00; 1.50]) compared to the control group (median: -3.00 kg [-9.50; 0.00], p<0.001). On the first postoperative day, the intervention group met significantly higher energy (mean ± SD: 60.6% ± 23.5%) and protein (median: 57.8%) requirements compared to the control group (39.1% ± 25.1% and 0.55%, respectively; p<0.001). From the second postoperative day onwards, the intervention group maintained over 95% of their energy requirement, while the control group remained at a significantly lower level. Conclusion: The new perioperative nutritional intervention program demonstrates superior efficacy in improving nutritional status and limiting postoperative weight loss. The application of this protocol is an important and effective strategy to enhance treatment outcomes.