RELATIONSHIP BETWEEN HYPONATREMIA AND NEUROLOGICAL FUNCTIONAL OUTCOMES IN PATIENTS WITH SUBARACHNOID HEMORRHAGE DUE TO RUPTURED CEREBRAL ANEURYSMS AT BACH MAI HOSPITAL 2023-2025
Main Article Content
Abstract
Aneurysmal subarachnoid hemorrhage (SAH) is a severe neurological emergency associated with high rates of mortality and disability. The assessment of epidemiological, clinical, radiological characteristics, and risk factors plays an important role in prognosis and management. Among these, electrolyte disturbances, particularly hyponatremia, have been frequently reported after SAH. However, the prognostic value of serum sodium levels in neurological outcomes remains controversial. Objective: To describe the clinical and radiological characteristics and to analyze the association between serum sodium levels and neurological outcomes in patients with aneurysmal SAH. Subjects and Methods: A cross-sectional descriptive study was conducted on 428 patients diagnosed with aneurysmal SAH. Data collected included demographic, clinical, radiological characteristics, and serum sodium levels. Outcomes were assessed using the Glasgow Outcome Scale (GOS) and modified Rankin Scale (mRS) at discharge and at 30 days. Results: Serum sodium concentration was significantly associated with neurological outcomes (p < 0.05), but showed low predictive accuracy (AUC 0.580–0.591). Conclusion: Most patients were admitted in relatively preserved clinical condition. Serum sodium levels were associated with neurological outcomes, but their prognostic value remains limited.
Article Details
Keywords
Subarachnoid hemorrhage (SAH), Hyponatremia.
References
2. Etminan N, Chang HS, Hackenberg K, et al. Worldwide Incidence of Aneurysmal Subarachnoid Hemorrhage According to Region, Time Period, Blood Pressure, and Smoking Prevalence in the Population: A Systematic Review and Meta-analysis. JAMA Neurol. 2019;76(5):588-597. doi:10.1001/jamaneurol.2019.0006
3. Saleem S, Yousuf I, Gul A, Gupta S, Verma S. Hyponatremia in stroke. Ann Indian Acad Neurol. 2014;17(1):55-57. doi:10.4103/0972-2327.128554
4. Sherlock M, O’Sullivan E, Agha A, et al. The incidence and pathophysiology of hyponatraemia after subarachnoid haemorrhage. Clin Endocrinol (Oxf). 2006;64(3):250-254. doi:10.1111/j.1365-2265.2006.02432.x
5. E F Wijdicks, A H Ropper, E J Hunnicutt, G S Richardson, J A Nathanson. Atrial natriuretic factor and salt wasting after aneurysmal subarachnoid hemorrhage. | Stroke. Accessed September 1, 2025. https://www.ahajournals. org/doi/10.1161/01.str.22.12.1519?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat =cr_pub%20%200pubmed
6. Masami Shimoda, Shinri Oda, Yoshiaki Mamata, Ryuichi Tsugane, Osamu Sato. Surgical indications in patients with an intracerebral hemorrhage due to ruptured middle cerebral artery aneurysm. 87(2):170-175. doi:https://doi.org/10.3171/jns.1997.87.2.0170
7. Al-Mistarehi AH, Elsayed MA, Ibrahim RM, et al. Clinical Outcomes of Primary Subarachnoid Hemorrhage: An Exploratory Cohort Study from Sudan. The Neurohospitalist. 2022;12(2):249-263. doi:10.1177/19418744211068289
8. de Winkel J, Cras TY, Dammers R, et al. Early predictors of functional outcome in poor-grade aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. BMC Neurol. 2022;22(1):239.doi:10.1186/s12883-022-02734-x
9. Verbalis JG, Goldsmith SR, Greenberg A, et al. Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations. Am J Med. 2013;126(10 Suppl 1):S1-42. doi:10.1016/j.amjmed.2013.07.006
10. The incidence and pathophysiology of hyponatraemia after subarachnoid haemorrhage - Sherlock - 2006 - Clinical Endocrinology - Wiley Online Library. Accessed September 17, 2025. https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2006.02432.x?utm_source=chatgpt.com