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EFFICACY OF COMBINED CO₂ LASER AND ZINC SULFATE SOLUTION IN TREATING GENITAL WARTS
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Abstract
Objectives: To evaluate the efficacy of combining laser CO₂ therapy with zinc sulfate solution 0,1% compared to laser CO₂ monotherapy in treating genital warts. Materials and Methods: A randomized controlled trial was conducted on 75 male patients (aged 18–60) with external genital warts at the National Hospital of Dermatology and Venereology from November 2024 to July 2025. Participants were divided into two groups: Group 1 (n=35): Treated with laser CO2 followed by daily zinc sulfate solution 0.1% soak for 12 weeks. Group 2 (n=40): Treated with laser CO2 alone (applied only upon lesion detection). Outcomes included lesion clearance rate at weeks 4, 8, and 12, number of laser sessions required, and adverse effects. Results: Lesion Clearance at 12 Weeks: Group 1: 94.3% clearance Group 2: 87.5% clearance (No significant difference, p > 0.05). Laser Sessions Needed: 74.3% of Group 1 required one session vs 57.5% in Group 2 (p = 0.045). Safety: Mild side effects were comparable; zinc sulfate was well-tolerated. Conclusions: The combination of laser CO₂ and zinc sulfate significantly reduced the number of laser treatments without increasing adverse effects, offering a promising approach for persistent genital warts
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Keywords
Genital warts, HPV, laser CO2, zinc sulfate
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