ĐÁNH GIÁ ĐẶC ĐIỂM LÂM SÀNG, MÔ BỆNH HỌC, KẾT QUẢ ĐIỀU TRỊ UNG THƯ BIỂU MÔ TUYẾN BÃ Ở MI MẮT: BÁO CA LOẠT CA LÂM SÀNG

Abstract

Sebaceous gland carcinoma (SGC) of the eyelid is a rare but highly malignant tumor, most commonly arising from the Meibomian glands or the glands of Zeis. The disease primarily affects elderly individuals, particularly women, and is more frequently located on the upper eyelid. Clinically, SGC often presents with nonspecific features and may be misdiagnosed as benign conditions such as chalazion or chronic blepharitis, leading to delayed diagnosis and treatment. Histopathologically, the tumor is characterized by proliferation of cells with clear lipid-containing cytoplasm and basophilic nuclei; in some cases, immunohistochemical staining is required to confirm sebaceous differentiation. Wide local excision with histologically negative margins remains the mainstay of treatment. This report presents cases of eyelid SGC diagnosed and treated at the Vietnam National Eye Hospital, describing their clinical, histopathological characteristics, and treatment outcomes. The study aims to raise awareness of this rare but aggressive malignancy and emphasize the importance of early diagnosis and complete surgical excision in improving patient prognosis.