NỒNG ĐỘ HOMOCYSTEIN MÁU VỚI SỰ BIỂU HIỆN ĐẠM NIỆU Ở BỆNH NHÂN ĐÁI THÁO ĐƯỜNG TYPE 2 CÓ TĂNG HUYẾT ÁP

Abstract

Objective: Investigation of the association between blood homocysteine levels and proteinuria in patients with type 2 diabetes mellitus ((T2DM) with and without hypertension. Materials and Methods: A descriptive study was conducted on 160 participants recruited from the Department of General Internal Medicine and the Outpatient Clinic of Can Tho University of Medicine and Pharmacy Hospital from May 2023 to May 2025. Results: Participants aged ≥ 60 years accounted for 65.6%, with a mean age of 63.89 ± 12.82 years. Females represented 67.5%, approximately twice the proportion of males. The mean BMI and waist circumference were 23.34 ± 3.47 and 83.02 ± 9.56 cm, respectively. The mean blood homocysteine level was significantly higher in the hypertensive group compared to the non-hypertensive group (p < 0.001). The prevalence of proteinuria ≥ 30 mg/g was markedly higher in individuals with hypertension than in those without hypertension, with a statistically significant difference (p = 0.003). The mean level of proteinuria also differed significantly between the two groups (p = 0.049). Blood homocysteine levels were significantly higher in patients with proteinuria ≥ 30 mg/g than in those with < 30 mg/g (p < 0.001). Among patients within the same degree of proteinuria, those with both T2DM and hypertension consistently had higher mean homocysteine levels compared to those without hypertension. Conclusion: Elevated homocysteine may serve as a potential biomarker for the early detection of diabetic kidney disease, particularly in patients with type 2 diabetes mellitus and hypertension