NỒNG ĐỘ HOMOCYSTEIN MÁU VÀ SỰ BIỂU HIỆN ĐẠM NIỆU Ở BỆNH NHÂN ĐÁI THÁO ĐƯỜNG TYPE 2 CÓ RỐI LOẠN LIPID MÁU

Abstract

Background: Dyslipidemia and elevated blood homocysteine are important risk factors for renal complications in patients with type 2 diabetes mellitus (T2DM). Objective: To investigate blood homocysteine levels and their association with proteinuria in patients with T2DM with and without dyslipidemia. Materials and Methods: A cross-sectional descriptive study was conducted on 160 patients with T2DM, divided into two groups: those with dyslipidemia and those without. Results: The mean age of the study population was 63.89 ± 12.82 years, and females accounted for 67.5%. The mean blood homocysteine concentration was significantly higher in the dyslipidemia group than in the non-dyslipidemia group (8.37 ± 2.88 vs. 6.01 ± 1.83 µmol/L; p < 0.001). The prevalence of proteinuria (≥ 30 mg/g) was markedly higher in patients with dyslipidemia (75.0%) compared with those without (34.4%) (p < 0.001). Notably, the highest homocysteine levels were observed in patients who had both dyslipidemia and proteinuria (8.61 ± 3.17 µmol/L).Conclusion: Dyslipidemia in patients with T2DM is strongly associated with elevated blood homocysteine levels and a higher prevalence of proteinuria. The coexistence of dyslipidemia and proteinuria significantly increases homocysteine concentrations.