ĐẶC ĐIỂM TÌNH HÌNH NHIỄM KHUẨN BỆNH VIỆN DO KLEPBSIELLA PNEUMONIAE TẠI TRUNG TÂM CHỐNG ĐỘC GIAI ĐOẠN 2023-2025

Abstract

Objective: To investigate the situation of hospital-acquired infections caused by Klebsiella pneumoniae at the Poison Control Center, Bach Mai Hospital, during the period 2023–2025. Subjects and Methods: A retrospective cross-sectional study was conducted on 65 patients diagnosed with hospital-acquired infections due to K. pneumoniae from June 2023 to June 2025. Results: The mean age of patients was 56.8 ± 17.8 years; males accounted for 78.5% and females 21.5%. Chronic comorbidities were present in 76.9% of patients, with diabetes mellitus being the most common (24.6%). The predominant hospital-acquired infection caused by K. pneumoniae was ventilator-associated pneumonia (73.8%). K. pneumoniae exhibited very high resistance rates to ampicillin (86.2%), trimethoprim/ sulfamethoxazole (81.5%), third- and fourth-generation cephalosporins (70.8–75.4%), quinolones (73.8%), and carbapenems (64.6%). Higher susceptibility was observed to fosfomycin (81.1%), colistin (71.8%), ceftazidime/avibactam (66.2%), amikacin (64.4%), and gentamicin (47.7%). Conclusion: Hospital-acquired infections caused by K. pneumoniae at the Poison Control Center, Bach Mai Hospital, during 2023–2025 were mainly ventilator-associated pneumonia. The pathogen showed high resistance rates to cephalosporins, quinolones, and carbapenems, while remaining relatively susceptible to fosfomycin, colistin, and amikacin.