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A STUDY OF TILs EXPRESSION IN NON-SMALL CELL LUNG CARCINOMA
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Abstract
Introduction: Non-small cell lung cancer (NSCLC) is a common type of cancer with a high mortality rate. The prognostic role of tumor-infiltrating lymphocytes (TILs) in NSCLC remains controversial globally and has not yet been studied in Vietnam. The objective of this study was to survey the infiltration rate of TILs in NSCLC and evaluate its correlation with clinicopathological features. Methods: Cross-sectional description of 117 cases of patients diagnosed with primary non-small cell lung carcinoma at the University of Medicine and Pharmacy Hospital, Ho Chi Minh City and the Department of Embryology - Pathology, University of Medicine and Pharmacy, Ho Chi Minh City, between January 1, 2015 and January 1, 2024. TILs were assessed based on the guidelines for assessing TILs in solid tumors of the International Working Group on TILs. Results: The rate of patients with positive TILs expression (≥11%) was 29.1%. The study found a statistically significant correlation between TILs expression and smaller tumor size (p = 0.013), intermediate histological grade (grade 2) (p = 0.005), and the absence of tumor necrosis (p = 0.025). No significant association was found between TILs expression and age, sex, disease stage, or histological type. Conclusion: Lymphocyte infiltration is an important component of the NSCLC microenvironment, associated with tumor biological characteristics such as size, differentiation, and necrosis. This finding suggests the potential role of TILs as a prognostic factor, highlighting the need for further research to clarify the role of specific lymphocyte subpopulations to optimize immunotherapy for lung cancer patients in Vietnam.
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Keywords
Non-small cell lung cancer, Lung cancer, Tumor-infiltrating lymphocytes, TILs, Prognosis.
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