KHẢO SÁT ĐẶC ĐIỂM VÀ KIỂU HÌNH ĐỀ KHÁNG CARBAPENEM CỦA PSEUDOMONAS AERUGINOSA TẠI BỆNH VIỆN THỐNG NHẤT

Abstract

Objectives: To investigate the characteristics and resistance phenotypes of Pseudomonas aeruginosa isolated from patients examined and treated at Thong Nhat Hospital during 2024–2025. Materials and Methods: A cross-sectional study was conducted on P. aeruginosa strains isolated from all types of clinical specimens collected from patients at Thong Nhat Hospital between 2024 and 2025. Results: Among the 230 Pseudomonas aeruginosa isolates collected during the study period, most were from patients aged ≥ 60 years, primarily hospitalized in Internal Medicine wards. The most common specimen type was respiratory samples (51.3%). The rate of carbapenem resistance was 47.8% (110/230 isolates). Among the 110 carbapenem-resistant isolates, 74.5% (82/110) were carbapenemase-producing P. aeruginosa (CP-PA, mCIM positive), while 25.5% (28/110) were non–CP-PA. Conclusion: The study demonstrated that most carbapenem-resistant P. aeruginosa isolates obtained at Thong Nhat Hospital during 2024–2025 were carbapenemase producers, strongly associated with multidrug and extensively drug-resistant phenotypes. These findings highlight the necessity of stringent infection control measures and prudent antibiotic stewardship to prevent the spread of resistant strains within the hospital setting