CLINICAL AND SUBCLINICAL CHARACTERISTICS OF FUCHS ENDOTHELIAL CORNEAL DYSTROPHY
Main Article Content
Abstract
Objectives: Evaluation of the clinical and subclinical features of Fuchs endothelial corneal dystrophy. Subjectives and Method: A cross-sectional study. There were 23 patients (40 eyes) in 15 families, who had Fuchs endothelial corneal dystrophy, from August 2020 to July 2021. Results: There were 10 male patients and 13 female patients, with an average age of 58,0±14,6 years. All patients were affected in both eyes by this disease. Six patients were discovered by chance during other examinations or while examining other members of affected families. There were 17 patients who experienced blurred vision or eye irritation. Clinical examination revealed that 25 eyes had clear corneas, 15 had corneal edema, and 33 had corneal guttae. Because of corneal edema and scarring, the posterior surface of 7 eyes could not be detected. Endothelial cell count was 2310±515 cells/mm2 on average. The average corneal thickness in 40 patients was 593,8±67,9µm. Conclusion: Fuchs endothelial corneal dystrophy has typical clinical and subclinical features in Vietnam. Specular microscope and a corneal thickness measurement are important for following this disease.
Article Details
Keywords
Fuchs endothelial corneal dystrophy
References
2. Matthaei M, Hribek A, Clahsen T, Bachmann B, Cursiefen C, Jun AS. Fuchs Endothelial Corneal Dystrophy: Clinical, Genetic, Pathophysiologic, and Therapeutic Aspects. Annu Rev Vis Sci. Sep 15 2019;5:151-175. doi:10.1146/annurev-vision-091718-014852
3. Greene JB, Mian SI. Cataract surgery in patients with corneal disease. Curr Opin Ophthalmol. Jan 2013;24(1):9-14. doi:10.1097/ICU.0b013e32835aeec4
4. Malandain E, Gueudry J, Boutillier G, Muraine M. [Outcomes of cataract surgery in patients with Fuchs endothelial corneal dystrophy]. J Fr Ophtalmol. Oct 2021;44(8):1180-1189. Chirurgie de cataracte seule chez le patient porteur d'une dystrophie endotheliale de Fuchs. doi:10.1016/j.jfo.2020.09.033
5. Elhalis H, Azizi B, Jurkunas UV. Fuchs endothelial corneal dystrophy. Ocul Surf. Oct 2010; 8 (4):173-84. doi:10.1016/s1542-0124(12)70232-x
6. Lê Xuân Cung. Nhận xét đặc điểm lâm sàng và bệnh lý giải phẫu của bệnh loạn dưỡng giác mạc di truyền - gia đình. Luận văn tốt nghiệp bác sĩ nội trú bệnh viện. Trường đại học Y Hà Nội; 1999.
7. Kopplin LJ, Przepyszny K, Schmotzer B, et al. Relationship of Fuchs endothelial corneal dystrophy severity to central corneal thickness. Arch Ophthalmol. Apr 2012;130(4):433-9. doi:10.1001/archopthalmol.2011.1626 10.1001/archophthalmol.2011.1626
8. Pateras E, Koufala C. Comparison between OrbscanIIz, Pentacam, Ultrasound Pachymetry (Tomey SP-100) at Different Stages of Keratoconus. Ophthalmology Research An International Journal. 07/16 2020;13:7-33. doi:10.9734/OR/2020/v13i230163