KHẢO SÁT NỒNG ĐỘ M2BPGI HUYẾT THANH VÀ MỘT SỐ YẾU TỐ LIÊN QUAN Ở BỆNH NHÂN VIÊM GAN SIÊU VI B MẠN

Abstract

Background: Chronic hepatitis B (CHB) remains a major global health concern with a high prevalence, particularly in developing countries. Recent studies have demonstrated that serum Mac-2 binding protein glycosylation isomer (M2BPGi) levels are closely correlated with the degree of liver fibrosis and associated with several clinical factors. However, data from Vietnam remain limited. Objective: To investigate serum M2BPGi levels and explore factors associated with serum M2BPGi in patients with chronic hepatitis B. Materials and methods: A cross-sectional descriptive and analytical study was conducted on 43 patients diagnosed with CHB who attended Thong Nhat Dong Nai General Hospital from May 2025 to September 2025. Results: The male-to-female ratio was nearly equal, with a mean age of 48.21 ± 10.38 years. Nearly one-quarter of patients reported a family history of HBV infection, and 9.3% had relatives with cirrhosis or hepatocellular carcinoma. Hypertension was the most common comorbidity, accounting for 16.3%. Approximately two-thirds of patients were classified as fibrosis stage F2, while the remainder were in stages F0 or F1. About one-third of patients tested positive for M2BPGi, with 27.9% at 1+ and the rest at 2+. The median serum M2BPGi level was 0.82 COI. The highest M2BPGi concentrations were observed in patients aged over 60 years. A statistically significant positive correlation was found between M2BPGi levels and fibrosis stage from F0 to F2 (r = 0.331, p = 0.03). Furthermore, M2BPGi positivity was associated with an increased likelihood of advanced fibrosis classification, with an odds ratio of 5.6 (95% CI 1.06–29.59, p = 0.031). Conclusion: Approximately one-third of patients with chronic hepatitis B had positive serum M2BPGi levels. Serum M2BPGi was associated with older age and greater severity of liver fibrosis.