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FACTORS ASSOCIATED WITH CA125 AND NT-proBNP IN ACUTE HEART FAILURE
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Abstract
Background: Congestion is a primary symptom in patients with acute heart failure, but its clinical identification remains challenging. NT-proBNP is a standard biomarker for heart failure, reflecting vascular congestion rather than tissue congestion. This study investigates the relationship between clinical signs of congestion, right heart factors on echocardiography, and the biomarkers CA125 and NT-proBNP in patients with acute heart failure. Methods: This was a cross-sectional descriptive study involving 316 patients with acute heart failure. Symptoms of congestion, CA125, and NT-proBNP were assessed at the time of hospital admission. Echocardiography was performed during hospitalization. The relationship between clinical signs of congestion, right heart factors, and the biomarkers CA125 and NT-proBNP was evaluated using multiple regression coefficients (R²). Results: The average age of participants was 66.6 ± 14.8 years, with 164 (51.9%) being female. The majority of patients, 254 (80.4%), were admitted due to acute decompensated heart failure. The median (interquartile range) for NT-proBNP was 6.644 (3.973 – 12.360) pg/ml, and for CA125 it was 56 (27 – 140) U/mL. In the multivariate linear regression model, the most significant factor associated with changes in NT-proBNP was renal failure (R² = 0.1276, P < 0.001). NT-proBNP was found to be associated with the congestion index, but not with right heart factors. The most significant factor associated with changes in CA125 was the congestion index (R² = 0.0896, P < 0.001). CA125 was also associated with right heart factors, such as tricuspid regurgitation (R² = 0.0166, P = 0.025). Conclusions: In patients with acute heart failure, the most important factor associated with NT-proBNP is renal failure. For CA125, the key contributing factors are the congestion index and tricuspid regurgitation. These findings support the use of CA125 as a biomarker for congestion and right heart involvement in patients with acute heart failure
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Keywords
CA125, NT-proBNP, acute heart failure, congestion
References
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