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Date Published: 02/02/2026
Abstract Views: 57
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DOI: https://doi.org/10.51298/vmj.v558i2.17050
Issue
Vol. 558 No. 2 (2026)
Section
Các bài báo
How to Cite
Ngô, Đình T., Nguyễn, T. T., & Đỗ, V. N. (2026). A STUDY ON THE ASSOCIATION BETWEEN EARLY ALLOGRAFT DYSFUNCTION AND ACUTE KIDNEY INJURY AFTER LIVER TRANSPLANTATION. Vietnam Medical Journal, 558(2). https://doi.org/10.51298/vmj.v558i2.17050

A STUDY ON THE ASSOCIATION BETWEEN EARLY ALLOGRAFT DYSFUNCTION AND ACUTE KIDNEY INJURY AFTER LIVER TRANSPLANTATION

Đình Trung Ngô, Tài Thu Nguyễn, Văn Nam Đỗ

Main Article Content

Abstract

Objective: To evaluate the association between early allograft dysfunction (EAD) after liver transplantation and the risk of acute kidney injury (AKI). Methods: A prospective–retrospective descriptive study was conducted on 205 liver transplant recipients at 108 Military Central Hospital during 2020–2024. AKI was diagnosed according to KDIGO 2012 criteria, and EAD was defined based on Olthoff’s criteria. Clinical characteristics, laboratory results, perioperative factors, and post-transplant outcomes were analyzed. Results: A total of 81 patients (40%) developed AKI after transplantation. The AKI group showed higher MELD scores (17.0 ± 8.5 vs. 10.6 ± 7.1; p<0.05), longer warm ischemia time (37.9 ± 7.4 vs. 34.3 ± 8.5 minutes; p<0.05), higher lactate levels at 6 hours postoperatively (6.1 ± 2.2 vs. 5.3 ± 2.0 mmol/L; p<0.05), and a higher incidence of EAD (45.7% vs. 29.8%; p<0.05). Multivariate logistic regression revealed that MELD score (OR 1.160; 95% CI: 1.088–1.236; p<0.05) and EAD (OR 1.186; 95% CI: 1.027–1.370; p<0.05) were independent predictors of post-transplant AKI. Conclusion: AKI is a frequent complication after liver transplantation. High MELD score and early allograft dysfunction are independent predictors of AKI.

Article Details

Keywords

liver transplantation; early allograft dysfunction (EAD); acute kidney injury (AKI)

References

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