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Date Published: 02/02/2026
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DOI: https://doi.org/10.51298/vmj.v558i2.17066
Issue
Vol. 558 No. 2 (2026)
Section
Các bài báo
How to Cite
Nguyễn, V. H., Nguyễn, H. V., & Nguyễn, Q. T. (2026). EVALUATING NKG2D GENE RS1049174 VARIANT IN PATIENTS WITH TONSILLAR SQUAMOUS CELL CARCINOMA DURING 2018 - 2022. Vietnam Medical Journal, 558(2). https://doi.org/10.51298/vmj.v558i2.17066

EVALUATING NKG2D GENE RS1049174 VARIANT IN PATIENTS WITH TONSILLAR SQUAMOUS CELL CARCINOMA DURING 2018 - 2022

Văn Hùng Nguyễn, Hoàng Việt Nguyễn, Quang Trung Nguyễn

Main Article Content

Abstract

Purpose: The study was conducted to determine the association between rs1049174 of the NKG2D gene and the risk of tonsillar squamous cell carcinoma. Materials and methods: A cross-sectional, descriptive case-control study was conducted on two groups of subjects (case group and control group) using Realtime PCR method to determine genotype. Results: The number of CC genotypes in the disease group was statistically significant (p<0.05) compared to the control group, with rates of 25,8% and 15%, respectively. There was not a statistically significant difference between the distribution of the G allele and the C allele in both two groups (p>0,05).  Conclusion: The G SNP rs1049174 allele of the NKG2D gene has a protective role in reducing the risk of tonsillar squamous cell carcinoma and the C allele of the NKG2D gene has increased the risk of this cancer (showed in CC genotypes), which suggested that these SNPs can be used as biomarkers for screening, prognosis, and treatment for Vietnamese patients at risk of that cancer.

Article Details

Keywords

tonsillar squamous cell carcinoma, SNP rs1049174, C allele, G allele.

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