HIỆU QUẢ LIỆU PHÁP PROLOTHERAPY TRONG ĐIỀU TRỊ HỘI CHỨNG ỐNG CỔ TAY: BÁO CÁO HÀNG LOẠT CA

Abstract

Background: Carpal Tunnel Syndrome (CTS) is among the most common entrapment neuropathies, leading to pain, numbness, hand weakness, and reduced quality of life. Prolotherapy with hypertonic dextrose has shown promising regenerative and analgesic effects in various musculoskeletal disorders, but evidence for its efficacy in CTS remains limited. Methods: This case series included 25 patients diagnosed with mild to moderate CTS based on clinical examination and electrodiagnostic findings. All participants received 10% dextrose prolotherapy injections around the median nerve at carpal tunnel, administered two times at four-week intervals. Pain intensity was assessed using the NRS (Numberic Rating Scale), and functional outcomes were measured using the Boston Carpal Tunnel Questionnaire (BCTQ) before and after 2 injections. Results: After two sessions, the mean NRS pain score significantly decreased from 6.4 ± 1.2 to 2.1 ± 0.9 (p < 0.001). Functional improvement according to BCTQ was observed in 80% of patients. No serious adverse events or major complications were reported. Conclusion: Ten percent dextrose prolotherapy appears to be a safe, well-tolerated, and effective therapeutic option for patients with mild to moderate CTS. Larger randomized controlled trials are warranted to further confirm these findings and elucidate the underlying mechanisms of action.