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THE ROLE OF HBA1C TESTING IN PREDICTING THE RISK OF AMPUTATION IN PATIENTS WITH DIABETIC FOOT ULCERS
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Abstract
Objective: To investigate the association between HbA1c levels and the risk of lower-limb amputation in patients with diabetic foot ulcers. Methods: A cross-sectional study was conducted on 155 patients hospitalised with diabetic foot ulcers over a six-month period. Results: Our analysis showed that for every 1% increase in HbA1c, the odds of amputation increased by 28% (95% CI: 1.11–1.48, p = 0.001). The area under the curve (AUC) for HbA1c alone was 0.6553, while the multivariable model improved to 0.7625. The optimal cut-off value, determined by Youden’s J index, was 0.4189, yielding a sensitivity of 71.88%, specificity of 73.63%, positive predictive value (PPV) of 65.71%, and negative predictive value (NPV) of 78.82%. Conclusion: Elevated HbA1c was identified as an independent risk factor with moderate predictive value for lower-limb amputation. However, HbA1c alone is not an ideal screening tool and should be combined with other factors in a multivariable model to enhance predictive accuracy
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Keywords
HbA1c, diabetic foot ulcer, diabetes mellitus.
References
2. Huỳnh Tấn Đạt, Nguyễn Thy Khuê. Tỉ lệ và các yếu tố liên quan đoạn chi dưới ở bệnh nhân đái tháo đường có loét chân. Tạp Chí Học Thành Phố Hồ Chí Minh. 2024;27(2):89–98.
3. Bộ Y tế. Số:1530/QĐ-BYT. Hướng dẫn chẩn đoán, điều trị Loét bàn chân do đái tháo đường. 2023.
4. Moss SE, Klein R, Klein BEK. The Prevalence and Incidence of Lower Extremity Amputation in a Diabetic Population. [cited 2025 Aug 22];
5. Peng B, Min R, Liao Y, et al. Development of Predictive Nomograms for Clinical Use to Quantify the Risk of Amputation in Patients with Diabetic Foot Ulcer. Rothe U, editor. J Diabetes Res. 2021;2021:1–9.
6. Davis WA, Norman PE, Bruce DG, et al. Predictors, consequences and costs of diabetes-related lower extremity amputation complicating type 2 diabetes: The Fremantle Diabetes Study. Diabetologia. 2006;49(11):2634–2641.
7. Tạ Bình Minh, Nguyễn Thị Bích Đào. Nghiên cứu các yếu tố liên quan lành vết loét bàn chân trên bệnh nhân đái tháo đường típ 2 tại Khoa Nội tiết Bệnh viện Chợ Rẫy. Hội Nội Tiết – Đái Tháo Đường Miền Trung Việt Nam [Internet]. 2016;