KHẢO SÁT NỒNG ĐỘ KHÁNG THỂ KHÁNG NHÂN VÀ KHÁNG THỂ KHÁNG CHUỖI KÉP DNA Ở BỆNH NHÂN COVID-19

Abstract

Objective: To investigate the levels of  antinuclear antibodies and anti-double-stranded DNA antibodies in COVID-19 patients. Methods: A study of 100 COVID-19 inpatients with different severity and 25 non-COVID-19 patients was conducted. Of them, quantitative test for antinuclear antibodies using CLIA technique and quantitative test for  anti-double-stranded DNA antibodies using chemiluminescence method on Maglumi system. Results: There was no difference in antinuclear antibody levels, anti-Ds-DNA antibodies, and the proportion of patients with high levels of antinuclear antibody between the COVID-19 and non-COVID-19 groups, between the severe/critical COVID-19 group and the mild/moderate COVID-19 group. At the time of admission, elevated CRP was associated with severe and critical COVID-19 (OR = 5.571; 95%CI: 2.325 - 13.350; p < 0.05). Conclusion: More research with a larger number of patients is needed to determine the increased levels of  antinuclear antibody and anti-Ds DNA antibody in different severity of COVID-19 patients.