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Date Published: 03/02/2026
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DOI: https://doi.org/10.51298/vmj.v558i3.17124
Issue
Vol. 558 No. 3 (2026)
Section
Các bài báo
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Nguyễn , M. K., Lê , X. H., Chu , Đức P., & Đặng , V. L. (2026). TWO-STAGE REVISION KNEE ARTHROPLASTY FOR THE TREATMENT OF INFECTION AFTER TOTAL KNEE ARTHROPLASTY AT VIET DUC UNIVERSITY HOSPITAL. Vietnam Medical Journal, 558(3). https://doi.org/10.51298/vmj.v558i3.17124

TWO-STAGE REVISION KNEE ARTHROPLASTY FOR THE TREATMENT OF INFECTION AFTER TOTAL KNEE ARTHROPLASTY AT VIET DUC UNIVERSITY HOSPITAL

Mạnh Khánh Nguyễn 1,2, Xuân Hoàng Lê 1,2,, Đức Phong Chu 1, Văn Long Đặng 1
1 Vietduc University Hospital
2 University of Medicine and Pharmacy, Vietnam National University, Hanoi

Main Article Content

Abstract

Objective: To review the indications and evaluate the outcomes of two-stage revision knee arthroplasty for infection following total knee arthroplasty at Viet Duc University Hospital. Materials and Methods: Patients who underwent two-stage revision for periprosthetic joint infection after total knee arthroplasty at Viet Duc University Hospital from 2022–2025 were included. Descriptive study. Results: Four patients with chronic infection were analyzed (3 females, 1 male); mean age 67.25 ± 13.84 years (range, 54–82). Microbiology: Staphylococcus aureus in 75% (MRSA 50%, MSSA 25%); 25% were culture-negative. The typical systemic antibiotic regimen was vancomycin combined with gentamicin and ciprofloxacin/levofloxacin for 4–8 weeks; one culture-negative case received prolonged therapy for 1 year. After placement of an antibiotic spacer, all 4/4 patients underwent reimplantation with a hinged knee prosthesis once infection control was achieved. The latest functional outcomes were favorable: ROM ≈ 100°, VAS 0–4, and one patient required a walking cane. Conclusion: Two-stage revision achieved reliable infection control and favorable functional outcomes in this series (ROM ≈ 100°, VAS 0–4). Outcomes were influenced by pathogen type (notably MRSA), local soft-tissue condition, inflammatory markers, interstage interval, and adherence to antibiotic therapy.

Article Details

Keywords

Total knee arthroplasty, periprosthetic joint infection, spacer, antibiotics, two-stage revision.

References

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