LEVELS OF SERUM CRP, ALBUMIN, GLOBULIN IN PSORIASIS ULGARIS AND RELATIONSHIPDEGREE OF THE DISEASE

Nguyễn Thị Tài Linh1,, Đặng Văn Em2, Vũ Thái Hà3
1 Thai Binh University of Medicine and Pharmacy
2 108 Military Central Hospital
3 National Hospital of Dermatology and Venereology

Main Article Content

Abstract

Objective: to determine levels of CRP, albumin, and globulin serum levels of patients with psoriasis vulgaris and their relationship degree of the disease. Method: cross sectional description; including 2 groups: Study group 55 patients with psoriasis vulgaris; 55 healthy people in the control group at the National Hospital of Dermatology. Results: The study group increased CRP concentration in serum and the CRP/Albumin ratio was higher than the control group (p<0.001) and was related to degree of the disease. In contrast, the serum albumin concentration of the study group (39.41 ± 3.74 g/l) decreased compared to the control group (42.21 ± 2.46 g/l) with p<0,001 and had a inversely related with degree of the disease. Serum globulin concentrations between study group (30.09±3.19g/l) and control group (29.11 ± 3.16 g/l) were similar (p> 0.05). Conclusion: There was an increase in CRP level,  CRP/Albumin ratio, decreasd in serum albumin concentration in patients with psoriasis vulgaris and the change is related to degree of disease.

Article Details

References

1. Nguyễn Thị Thùy Dung (2018). Xác định nồng độ hs-CRP huyết thanh bệnh nhân vảy nến thể mảng tại Bệnh viện Da liễu thành phố Hồ Chí Minh. Tạp chí Y học TP Hồ Chí Minh, 22(1), 107–113.
2. Tanaka T., Narazaki M., và Kishimoto T. (2014). IL-6 in Inflammation, Immunity, and Disease. Cold Spring Harb Perspect Biol, 6(10), a016295.
2. Nickoloff B.J. (2007). Cracking the cytokine code in psoriasis. Nat Med, 13(3), 242–244.
3. Worm A.M. và Rossing N. (1977). Transcapillary escape rate of albumin and plasma volume in patients with varying degrees of psoriasis. Br J Dermatol, 97(4), 423–427.
4. Sheikh G., và cộng sự. (2015). Comparison of levels of serum copper, zinc, albumin, globulin and alkaline phosphatase in psoriatic patients and controls: A hospital based casecontrol study. Indian Dermatol Online J, 6(2), 81–83.
6. Gisondi P., Malerba M., Malara G. và cộng sự. (2010). C-reactive protein and markers for thrombophilia in patients with chronic plaque psoriasis. Int J Immunopathol Pharmacol, 23(4), 1195–1202.
7. Staberg B., Worm A.-M., Klemp P. và cộng sự. (1983). Transvascular transport and distribution of fluid and protein in psoriasis. Journal of the American Academy of Dermatology, 8(2), 193–199.