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EFFICACY OF COLLAGEN CROSSLINKING FOR KERATOCONUS: ONE YEAR RESULTS
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Abstract
Introduction: CrossLinking (CXL) is a therapeutic procedure to decrease and halt the progression of keratoconus, which has become more popular and promising, but there has been no report in Viet Nam. Objective: To evaluate the safety and efficacy of accelerated CXL with riboflavin for keratoconus. Methods: Case series study, a total 147 eyes of 95 patients (11-31 years old) were included in this prospective study. Progressive and high risk keratoconic patients (age < 18 yrs old) underwent accelerated CXL at Refractive Department, Ho Chi Minh city Eye hospital. Pre-op parameters: UCVA, BCVA, SE, Kmax, flat K1, steep K2, ARC, PRC, astigmatism, corneal thickness, endothelium and complications (delayed epithelial healing, corneal ulcer, haze) were evaluated one year after the procedure. Results: The total number of involved eyes was 147. LogMar UCVA at pre-op 0.98 ± 0.39 and one year post-op 0.88±0.37 (P<0.05), BCVA 0.39 ± 0.31 và 0.38 ± 0.27 (P>0.05), respectively. The mean SE, astigmatism decreased but were not statistically significant. Kmax, K1, K2 post-op (61.86 ± 7.46D, 48.49 ± 4.86D, 54.54 ± 5.44D) decreased significantly when compared with pre-op (62.97 ± 7.57D, 48.75 ± 4.63D, 55.03 ± 5.26D) with P<0.001. ARC increased significantly when compared with pre-op (6.28 ± 0.62, 6.20 ± 0.58) with P<0.001, PRC were not changed. Corneal thickness was decreased significantly; endothelial cells were not changed. No complication was found during or after the surgery. Conclusion: Accelerated CXL is a safe and efficacy treatment for keratoconus.
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Keywords
CrossLinking, CXL, Keratoconus
References
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