KHẢO SÁT MỘT SỐ YẾU TỐ VI LƯỢNG VÀ MỐI LIÊN QUAN VỚI CO GIẬT DO SỐT ĐƠN THUẦN TẠI BỆNH VIỆN ĐA KHOA XANH PÔN

Abstract

Objective: To investigate the association between selected micronutrients and simple febrile seizures (SFS) in children under five years of age. Subjects and methods: A case-control study was conducted on 122 children at Saint Paul Hospital from July 2024 to June 2025. The case group consisted of children diagnosed with simple febrile seizures; the control group included age-matched febrile children without seizures. Serum levels of vitamin D, iron, ferritin, calcium, and zinc were measured. Logistic regression analysis was applied to assess associations. Results: Most children with SFS were between 12 and 24 months of age. Associated risk factors included a family history of febrile seizures and fever ≥39°C. The case group exhibited significantly lower levels of hemoglobin and micronutrients such as iron, calcium, zinc, and magnesium compared to the control group. Multivariate logistic regression analysis indicated that anemia (OR = 3.02; 95% CI: 1.19–7.65; p = 0.02), iron deficiency (OR = 7.44; 95% CI: 1.37–40.42; p = 0.02), calcium deficiency (OR = 10.2; 95% CI: 1.01–103.38; p = 0.03), and zinc deficiency (OR = 5.91; 95% CI: 1.27–47.34; p = 0.026) were significantly associated with increased risk of SFS. Conclusions: The findings suggest that anemia, iron deficiency, calcium deficiency, and zinc deficiency are significant risk factors for simple febrile seizures in young children.