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SURVEY OF THYROGLOBULIN CONCENTRATION IN PATIENTS WITH PAPILLARY THYROID CARCINOMA AFTER TOTAL THYROIDECTOMY
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Abstract
Objectives: This study aims to investigate serum Thyroglobulin (Tg) levels after total thyroidectomy and the relationship between serum Tg levels and thyroid cancer (TC) stages in patients with papillary thyroid carcinoma (PTC). Methods: Retrospective study of 160 papillary thyroid cancer patients after total thyroidectomy from 01/2023 to 07/2024 at Cho Ray Hospital. Results: The rate of women with PTC had 7,94 times higher than men. The stage of disease after total thyroidectomy with the highest rate is stage I (76.68%); 13.12% of patients have concomitant Hashimoto's thyroiditis (HT). Median serumTg levels decreased significantly (p<0,05), from 3,5 ng/mL after thyroidectomy to 0,14 ng/mL after radioactive Iodine treatment. In the group of patients with only PTC, serumTg levels was significantly higher (3,79 ng/mL) than in the group with PTC and Hashimoto's thyroiditis (0,69 ng/mL); this difference was statistically significant (p < 0.05). There was a weak positive correlation between lymph node and serumTg levels at postoperative with r = 0.2 and p < 0,05. Conclusion: There was a weak positive correlation between lymph node and serumTg levels at postoperative. There is no association between serum Tg levels and the stages of papillary thyroid cancer after total thyroidectomy.
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Keywords
Papillary Thyroid Carcinoma, Thyroglobulin, total thyroidectomy.
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